Enhanced suppression of <i>Stenotrophomonas maltophilia</i> by a three-phage cocktail: genomic insights and kinetic profiling.

ABSTRACT: Stenotrophomonas maltophilia is an understudied, gram-negative, aerobic bacterium that is widespread in the environment and increasingly a cause of opportunistic infections. Treating S. maltophilia remains difficult, leading to an increase in disease severity and higher hospitalization rates in people with cystic fibrosis, cancer, and other immunocompromised health conditions. The lack of effective antibiotics has led to renewed interest in phage therapy; however, there remains a great need for well-characterized phages, especially against S. maltophilia. In response to an oncology patient with a sepsis infection, we collected 18 phages from Southern California wastewater influent that exhibit different plaque morphology against S. maltophilia host strain B28B.

SUBMITTER: Monsibais AN 

PROVIDER: S-EPMC11881566 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature