The stress-protectant molecule trehalose mediates fluconazole tolerance in <i>Candida glabrata</i>.

ABSTRACT: The incidence of non-albicans Candida infections has witnessed a substantial rise in recent decades. Candida glabrata (Nakaseomyces glabratus), an opportunistic human fungal pathogen, is accountable for both superficial mucosal and life-threatening bloodstream infections, particularly in immunocompromised individuals. Distinguished by its remarkable resilience to environmental stressors, C. glabrata exhibits intrinsic tolerance to azoles and a high propensity to swiftly develop azole resistance during treatment. The molecular mechanism for the high tolerance is not fully understood. In this work, we investigated the possible role of trehalose in this tolerance. We generated mutants in the C. glabrata TPS1, TPS2, and NTH1 genes, encoding trehalose 6

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC11881567 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature