Altered triple network model connectivity is associated with cognitive function and depressive symptoms in older adults.

ABSTRACT:

Introduction

Late-life cognitive impairment and depression frequently co-occur and share many symptoms. However, the specific neural and clinical factors contributing to both their common and distinct profiles in older adults remain unclear.

Methods

We investigated resting-state correlates of cognitive and depressive symptoms in older adults (n = 248 and n = 95) using clinical, blood, and neuroimaging data. We computed a connectivity matrix across default mode, executive control, and salience networks. Cross-validated elastic net regression identified features reflecting cognitive function and depressive symptoms. These features were validated on a held-out dataset.

Results

We discovered that white matter hyperintensities and nine overlapping nodes spanning all three

SUBMITTER: Kolobaric A 

PROVIDER: S-EPMC11881620 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature