Plasma N-terminal tau fragment is an amyloid-dependent biomarker in Alzheimer's disease.

ABSTRACT:

Introduction

Novel fluid biomarkers for tracking neurodegeneration specific to Alzheimer's disease (AD) are greatly needed.

Methods

Using two independent well-characterized cohorts (n = 881 in total), we investigated the group differences in plasma N-terminal tau (NT1-tau) fragments across different AD stages and their association with cross-sectional and longitudinal amyloid beta (Aβ) plaques, tau tangles, brain atrophy, and cognitive decline.

Results

Plasma NT1-tau significantly increased in symptomatic AD and displayed positive associations with Aβ PET (positron emission tomography) and tau PET. Higher baseline NT1-tau levels predicted greater tau PET, with 2- to 10-year intervals and faster longitudinal Aβ PET increases, AD-typical neurodegeneration, and cognitive

SUBMITTER: Lan G 

PROVIDER: S-EPMC11881634 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature