Systematic review and meta-analysis of bulk RNAseq studies in human Alzheimer's disease brain tissue.

ABSTRACT: We systematically reviewed and meta-analyzed bulk RNA sequencing (RNAseq) studies comparing Alzheimer's disease (AD) patients to controls in human brain tissue. We searched PubMed, Web of Science, and Scopus for human brain bulk RNAseq studies, excluding re-analyses and studies limited to small RNAs or gene panels. We developed 10 criteria for quality assessment and performed a meta-analysis on three high-quality datasets. Of 3266 records, 24 qualified for the systematic review, and one study with three datasets qualified for the meta-analysis. The meta-analysis identified 571 differentially expressed genes (DEGs) in the temporal lobe and 189 in the frontal lobe, including CLU and GFAP. Pathway analysis suggested reactivation of developmental processes in the adult AD brain. Limited data a

SUBMITTER: Aguzzoli Heberle B 

PROVIDER: S-EPMC11881636 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature