DeepES: deep learning-based enzyme screening to identify orphan enzyme genes.

ABSTRACT:

Motivation

Progress in sequencing technology has led to determination of large numbers of protein sequences, and large enzyme databases are now available. Although many computational tools for enzyme annotation were developed, sequence information is unavailable for many enzymes, known as orphan enzymes. These orphan enzymes hinder sequence similarity-based functional annotation, leading gaps in understanding the association between sequences and enzymatic reactions.

Results

Therefore, we developed DeepES, a deep learning-based tool for enzyme screening to identify orphan enzyme genes, focusing on biosynthetic gene clusters and reaction class. DeepES uses protein sequences as inputs and evaluates whether the input genes contain biosynthetic gene clusters of interest by integ

SUBMITTER: Hirota K 

PROVIDER: S-EPMC11881691 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature