Utility of caregiver signaling questions to detect neurocognitive impairment in children with sickle cell disease.

ABSTRACT:

Abstract

The American Society of Hematology cerebrovascular guidelines for sickle cell disease (SCD) recommend surveillance using signaling questions to screen for neurocognitive difficulties, although the clinical utility of these signaling questions has yet to be established. This study aimed to determine the clinical utility of caregiver signaling questions for detecting significant neurocognitive impairment (defined as >1.5 standard deviation [SD] below the normative mean on ≥2 measures) and domain-specific impairment (defined as >1.5 SD below the normative mean) in children and adolescents with SCD. A total of 421 caregivers of children with SCD aged 8 to 17 years (62% hemoglobin SS (HbSS) or hemoglobin S-beta zero (HbSβ0) thalassemia) were asked 7 signaling questions. Childre

SUBMITTER: Dandar CM 

PROVIDER: S-EPMC11881744 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature