Dose optimization of cefazolin in South African children undergoing cardiac surgery with cardiopulmonary bypass.

ABSTRACT: Cefazolin is an antibiotic used to prevent surgical site infections. During cardiac surgery with cardiopulmonary bypass (CPB), its efficacy target could be underachieved. We aimed to develop a population pharmacokinetic model for cefazolin in children and optimize the prophylactic dosing regimen. Children under 25 kg undergoing cardiac surgery with CPB and receiving cefazolin at standard doses (50 mg/kg IV every 4-6 h) were included in this analysis. A population pharmacokinetic model and Monte Carlo simulations were used to evaluate the probability of target attainment (PTA) for efficacy and toxicity with the standard regimen and an alternative regimen of continuous infusion, where loading and maintenance doses were calculated from model-derived individual parameters. Twenty-two patients

SUBMITTER: Gebreyesus MS 

PROVIDER: S-EPMC11881764 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature