<i>Rhodococcus</i> spp. interacts with human norovirus in clinical samples and impairs its replication on human intestinal enteroids.

ABSTRACT: Viral infections, particularly human norovirus (NoV), are a leading cause of diarrheal diseases globally. To better understand NoV susceptibility, it is crucial to investigate both host glycobiology and the influence of the microbiota. Histo-blood group antigens (HBGA) displayed on surfaces of host cells act as NoV receptors, while certain bacteria express HBGA-like substances, facilitating virus-bacteria interactions. To identify bacterial species interacting with NoV during infection, stool samples from children infected with NoV GII.4 were analyzed. The samples were subjected to bacteria separation using anti-NoV GII.4 polyclonal antibodies coupled to magnetic beads, followed by microbiota profiling through 16S rDNA sequencing. This approach identified the genus Rhodococcus as en

SUBMITTER: Santiso-Bellon C 

PROVIDER: S-EPMC11881836 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature