Dopamine stabilized in ultra-nanoreservoirs for controlled delivery in parkinson's disease.

ABSTRACT:

Aims

Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to impaired dopamine (DA) signaling and motor control. Intermittent dosing of current DA precursors results in side effects, prompting research into controlled drug release mechanisms for sustained and targeted delivery of DA.

Materials & methods

In this work, we stabilized DA within a nanostructured silicate matrix (nanoreservoir) using the sol-gel method. We examined the physicochemical properties, kinetics of drug release, and biocompatibility in dopaminergic neurons and fibroblasts.

Results

The optimized synthesis method allowed for the stabilization of DA by preventing its oxidation. The physic

SUBMITTER: Padilla-Godinez FJ 

PROVIDER: S-EPMC11881884 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature