Donor HLA-DQ genetic and functional divergence affect the control of BK polyoma virus infection after kidney transplantation.

ABSTRACT: BK polyomavirus (BKPyV) infection remains a major concern after kidney transplantation, increasing the risk of graft loss in the absence of specific antiviral agent now available. Here, we investigated the impact of HLA diversity on the control of posttransplant BKPyV replication. High HLA evolutionary divergence (HED) at the DQ locus in the donor was an independent predictor of BKPyV-free outcome. More generally, we highlighted the protective effect of highly divergent pairs of HLA-DQ heterodimers corresponding to heterozygous HLA-DQα01/non-DQα01 combinations. We then defined a functional divergence metrics assessed by the similarity of peptide-binding motifs between pairs of HLA-DQ molecules. Greater functional divergence correlated with the size of the BKPyV-derived DQ-bound immunopepti

SUBMITTER: Chevalier MF 

PROVIDER: S-EPMC11881896 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature