Immunomodulatory role of the stem cell circadian clock in muscle repair.

ABSTRACT: Circadian rhythms orchestrate physiological processes such as metabolism, immune function, and tissue regeneration, aligning them with the optimal time of day (TOD). This study identifies an interplay between the circadian clock within muscle stem cells (SCs) and their capacity to modulate the immune microenvironment during muscle regeneration. We reveal that the SC clock triggers TOD-dependent inflammatory gene transcription after injury, particularly genes related to neutrophil activity and chemotaxis. These responses are driven by cytosolic regeneration of the signaling metabolite nicotinamide adenine dinucleotide (oxidized form) (NAD⁺), as enhancing cytosolic NAD⁺ regeneration in SCs is sufficient to induce inflammatory responses that influence muscle regeneration

SUBMITTER: Zhu P 

PROVIDER: S-EPMC11881903 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature