Bulbillosins A - E, azaphilones from <i>Tengochaetabulbillosa</i> sp. nov. (<i>Chaetomiaceae</i>), a root endophyte of the Chinese medicinal plant <i>Astertataricus</i>.

ABSTRACT: Astertataricus is a plant used in Traditional Chinese Medicine. From its roots, we isolated four endophytic fungi strains. After mass spectrometry analysis and subsequent molecular networking and dereplication, one of the strain's extracts showed a cluster of yet undescribed natural products. Additionally, the extract was found to be lethal for the nematode Caenorhabditiselegans and cytotoxic against eukaryotic cell lines. The fungal strain was characterized by morphological and molecular studies, allowing its description as a new species in the genus Tengochaeta (Chaetomiaceae), Tengochaetabulbillosa. After cultivation and extraction of the strain, the major secondary metabolites were isolated. Structure elucidation based on nuclear magnetic resonance spectroscopy and

SUBMITTER: Barrera-Adame DA 

PROVIDER: S-EPMC11882021 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature