Spatiotemporal feature learning for actin dynamics.

ABSTRACT: The social amoeba Dictyostelium discoideum is a standard model system for studying cell motility and formation of biological patterns. D. discoideum cells form protrusions and migrate via cytoskeletal reorganization driven by coordinated waves of actin polymerization and depolymerization. Assembly and disassembly of actin filaments are regulated by a complex network of biochemical reactions, exhibiting sensitivity to external physical cues such as stiffness, composition and surface topography of the extracellular matrix, as well as the presence of external electric fields. In this study, we investigate whether the cellular microenvironment, and in particular the presence of electric fields and the nano-topography type, can be directly inferred from images or videos of actin waves. We emplo

SUBMITTER: Saha S 

PROVIDER: S-EPMC11882080 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature