Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6.

ABSTRACT:

Purpose

Breast cancer brain metastasis remains a significant clinical problem. Mucins have been implicated in metastasis; however, whether they are also involved in breast cancer brain metastasis remains unknown. We queried databases of patients with brain metastasis and found mucin 5AC (MUC5AC) to be upregulated and therefore sought to define the role of MUC5AC in breast cancer brain metastasis.

Experimental design

In silico dataset analysis, RNA-sequence profiling of patient samples and cell lines, analysis of patient serum samples, and in vitro/in vivo knockdown experiments were performed to determine the function of MUC5AC in breast cancer brain metastasis. Coimmunoprecipitation was used to unravel the interactions that can be therapeutically targeted.

Results

Glo

SUBMITTER: Maurya SK 

PROVIDER: S-EPMC11882111 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature