Left Ventrolateral Prefrontal Cortical Activity During Reward Expectancy and Mania Risk.

ABSTRACT:

Importance

Mania/hypomania is the pathognomonic feature of bipolar disorder (BD). As BD is often misdiagnosed as major depressive disorder (MDD), replicable neural markers of mania/hypomania risk are needed for earlier BD diagnosis and pathophysiological treatment development.

Objective

To replicate the previously reported positive association between left ventrolateral prefrontal cortex (vlPFC) activity during reward expectancy (RE) and mania/hypomania risk, to explore the effect of MDD history on this association, and to compare RE-related left vlPFC activity in individuals with and at risk of BD.

Design, setting, and participants

This cross-sectional study was conducted from July 2014 to December 2023 at the University of Pittsburgh, Pittsburgh, Pennsylvania. Three

SUBMITTER: Arora M 

PROVIDER: S-EPMC11882368 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature