Direct minimization of normal-tissue toxicity via an NTCP-based IMPT planning method.

ABSTRACT:

Background

Intensity-modulated proton therapy (IMPT) planning often relies on physical dose constraints to balance tumor control and sparing of organs at risk (OARs). However, focusing solely on these dose objectives does not always minimize the normal-tissue toxicity, which is quantified as normal tissue complication probability (NTCP). NTCP is also a quantitative criterion for patient selection between proton and photon treatments.

Purpose

This study introduces an NTCP-based IMPT planning (NTCP-IMPT) method designed to directly minimize normal-tissue toxicity while maintaining tumor coverage.

Methods

NTCP-IMPT simultaneously optimizes NTCP and dose-volume histogram (DVH)-based physical dose objectives while adhering to the minimum-monitor-unit (MMU) constraint for p

SUBMITTER: Wang W 

PROVIDER: S-EPMC11882377 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature