Apolipoprotein E genotype is associated with island sign in lobar intracerebral hemorrhage.

ABSTRACT:

Background

The island sign is a predictor of hematoma expansion and worse outcomes in patients of spontaneous primary intracerebral hemorrhage (ICH). The biological mechanism of the island sign remains unclear, but its presence might be influenced by the underlying vasculopathy related to Apolipoprotein E (APOE) genotypes. Therefore, we aimed to research the association between APOE genotypes and the island sign.

Methods

We enrolled patients with primary supratentorial ICH in a multicenter cohort in northern China with baseline noncontrast CT images performed within 14 days after symptoms onset and APOE genotype available. The island sign was rated on the CT images according to validated criteria. Univariable and multivariable analyses were used to ident

SUBMITTER: Yang Q 

PROVIDER: S-EPMC11882416 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature