Short-term fasting before living kidney donation has an immune-modulatory effect.

ABSTRACT:

Background

Short-Term Fasting (STF) is an intervention reducing the intake of calories, without causing undernutrition or micronutrient-related malnutrition. It aims to systemically improve resilience against acute stress. Several (pre-)clinical studies have suggested protective effects of STF, marking the systemic effects STF can induce in respect to surgery and ischemia-reperfusion injury. In addition, STF also affects the number of circulating immune cells. We aim to determine the effect of STF on the abundance and phenotype of different immune cell populations.

Methods

Thirty participants were randomly selected from the FAST clinical trial, including living kidney donors, randomized to an STF-diet or control arm. In an observational cohort sub-study we prospectively incl

SUBMITTER: Oudmaijer CAJ 

PROVIDER: S-EPMC11882433 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature