Thermodynamic modeling of RsmA - mRNA interactions capture novel direct binding across the <i>Pseudomonas aeruginosa</i> transcriptome.

ABSTRACT: Pseudomonas aeruginosa (PA) is a ubiquitous, Gram-negative, bacteria that can attribute its survivability to numerous sensing and signaling pathways; conferring fitness due to speed of response. Post-transcriptional regulation is an energy efficient approach to quickly shift gene expression in response to the environment. The conserved post-transcriptional regulator RsmA is involved in regulating translation of genes involved in pathways that contribute to virulence, metabolism, and antibiotic resistance. Prior high-throughput approaches to map the full regulatory landscape of RsmA have estimated a target pool of approximately 500 genes; however, these approaches have been limited to a narrow range of growth phase, strain, and media conditions. Computational modeling presents a cond

SUBMITTER: Lukasiewicz AJ 

PROVIDER: S-EPMC11882435 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature