SARS-CoV-2 evolution on a dynamic immune landscape.

ABSTRACT: Since the onset of the pandemic, many SARS-CoV-2 variants have emerged, exhibiting substantial evolution in the virus' spike protein¹, the main target of neutralizing antibodies². A plausible hypothesis proposes that the virus evolves to evade antibody-mediated neutralization (vaccine- or infection-induced) to maximize its ability to infect an immunologically experienced population^1,3. Because viral infection induces neutralizing antibodies, viral evolution may thus navigate on a dynamic immune landscape that is shaped by local infection history. Here we developed a comprehensive mechanistic model, incorporating deep mutational scanning data^4,5, antibody pharmacokinetics and regional genomic surveillance data, to predict the variant-specific rela

SUBMITTER: Raharinirina NA 

PROVIDER: S-EPMC11882442 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature