Microvascular heterogeneity exploration in core and invasive zones of orthotopic rat glioblastoma via ultrasound localization microscopy.

ABSTRACT:

Background

We studied the microvascular structure and function of in situ glioblastoma using ultrasound localization microscopy (ULM).

Methods

The in vivo study was conducted via craniotomy in six Sprague-Dawley rats. Capillary pattern, capillary hemodynamics, and functional quantitative parameters were compared among tumor core, invasive zone, and normal brain tissue with ex vivo micro-computed tomography (micro-CT) and scanning electron microscopy. Correlations between quantitative parameters and histopathological vascular density (VD-H), proliferation index, and histopathological vascular maturity index (VMI-H) were evaluated. Kruskal-Wallis H, ANOVA, Mann-Whitney U, Pearson, and Spearman correlation statistics were used.

Results

Compared to the tumor core, the inv

SUBMITTER: Hu X 

PROVIDER: S-EPMC11882483 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature