Molecular epidemiology and patient outcome of carbapenem-resistant <i>Enterobacterales, Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> in Japan: a multicenter study from MultiDrug-Resistant organisms clinical research network.

ABSTRACT:

Background and objectives

Carbapenem-resistant Gram-negative bacilli (CRGNB), especially Enterobacterales, Pseudomonas aeruginosa and Acinetobacter baumannii, are critical pathogens associated with excess morbidity and mortality. To elucidate their molecular epidemiology and clinical outcomes in Japan, patients with CRGNB were enrolled in the MDR organisms clinical research network (MDRnet) consisting of eight tertiary care facilities.

Methods

Between 2019 and 2022, 246 unique patients with carbapenem-resistant Enterobacterales (CRE), carbapenem-resistant P. aeruginosa (CRPA) and carbapenem-resistant A. baumannii (CRAB) isolates were prospectively enrolled.

Results

A total of 246 isolates were collected from 246 patients, including 7

SUBMITTER: Saito S 

PROVIDER: S-EPMC11882498 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature