Development and validation of a nomogram for predicting the outcome of metabolic syndrome among people living with HIV after antiretroviral therapy in China.

ABSTRACT:

Background

The prevalence of metabolic syndrome among people living with HIV (PLWH) is increasing worldwide. This study aimed to develop and validate a nomogram to predict the risk of metabolic syndrome in PLWH receiving antiretroviral therapy (ART) in China, accounting for both traditional and HIV-specific risk factors.

Methods

A retrospective cohort study was conducted among PLWH receiving ART at a designated treatment center in Yinzhou District, China. A total of 774 patients were randomly assigned to development and validation cohorts in a 5:5 ratio. Predictive variables were identified using the least absolute shrinkage and selection operator and multivariable Cox regression analysis. The model's discriminative ability was assessed using the C-index and the area under t

SUBMITTER: Jin Y 

PROVIDER: S-EPMC11882517 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature