Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor 2 encephalitis with olfactory hallucination: a case report and literature review.

ABSTRACT: Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor encephalitis is a rare autoimmune disease divided into two subtypes, anti-AMPAR1 encephalitis and anti-AMPAR2 encephalitis, depending on the presence of autoantibodies targeting the GluR1 and GluR2 subunits of the AMPA receptor. The main manifestations are limbic encephalitis, including cognitive impairment, seizures, and psychiatric symptoms. The reported cases of anti-AMPAR encephalitis have grown; however, no research has yet described the clinical characteristics of each subtype. Herein, we present a case of a middle-aged woman with anti-AMPAR2 encephalitis who was admitted to the hospital with sudden-onset seizures. The physical examination did not show noteworthy findings, but the auxiliary examination revealed abnorm

SUBMITTER: Wang X 

PROVIDER: S-EPMC11882523 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature