β-lapachone suppresses carcinogenesis of cervical cancer via interaction with AKT1.

ABSTRACT:

Introduction

Cervical cancer is one of the most prevalent malignant tumors affecting women worldwide, and affected patients often face a poor prognosis due to its high drug resistance and recurrence rates. β-lapachone, a quinone compound originally extracted from natural plants, is an antitumor agent that specifically targets NQO1.

Methods

CC cells were treated with varying concentrations of β-lapachone to examine its effects on glucose metabolism, proliferation, metastasis, angiogenesis, and EMT in vitro. The targets and action pathways of β-lapachone were identified using network pharmacology and molecular docking, with KEGG pathway enrichment analysis. Its effects and toxicity were verified in vivo using a nude mouse xenograft model.

Results

β-lapacho

SUBMITTER: Du P 

PROVIDER: S-EPMC11882534 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature