Deciphering the role of CNIH4 in pan-cancer landscapes and its significance in breast cancer progression.

ABSTRACT:

Background

The escalating global cancer burden necessitates the development of biomarkers with enhanced specificity and sensitivity for early diagnosis and therapeutic efficacy monitoring. The CNIH4 gene, an emerging biomarker, is increasingly recognized for its role in the malignant progression across various cancers.

Methods

We conducted a comprehensive multi-omics analysis of CNIH4, including pan-cancer expression profiles, epigenetic alterations, immune microenvironment characteristics, and therapeutic response patterns. Our focus was on clinical features, molecular underpinnings, and drug sensitivity in breast cancer (BRCA) associated with CNIH4. In vitro studies were also performed to assess the effects of CNIH4 knockdown on cell proliferation and cell cycle in

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11882561 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature