Alterations in bile acid metabolites associated with pathogenicity and IVIG resistance in Kawasaki disease.

ABSTRACT:

Background

Kawasaki disease (KD) primarily affects children as an acute systemic vasculitis. Numerous studies indicated an elevated risk of cardiovascular disease due to metabolic disturbances. Despite this knowledge, the specific metabolic modes involved in KD remain unclear.

Methods

We examined the metabolome of individuals with 108 KD and 52 non-KD controls (KD vs. nKD) by ultraperformance liquid chromatography (UPLC) and tandem mass spectrometry (MS).

Results

Differential analysis uncovered the disturbed production of bile acids and lipids in KD. Furthermore, we investigated the impact of treatment, intravenous immunoglobulin (IVIG) resistance, and coronary artery (CA) occurrence on the metabolome. Our findings suggested that IVIG treatment alters the lipid and am

SUBMITTER: Wang X 

PROVIDER: S-EPMC11882569 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature