The Genetic Specificity of Cognitive Tests After Controlling for General Cognitive Ability.

ABSTRACT: Diverse tests of cognitive abilities correlate about 0.30 phenotypically and about 0.60 genetically. Their phenotypic overlap defines general cognitive ability (g), driven largely by genetic overlap. Consequently, much of our understanding of the genetic landscape of specific cognitive tests likely reflects g rather than the tests themselves. Removing this g-associated genetic variance will sharpen research on cognitive tests. Here, we use Genomic Structural Equation Modelling (Genomic SEM) to remove shared genetic variance among 12 diverse cognitive tests that capture verbal and nonverbal cognitive domains. We applied Genomic SEM to summary statistics from the largest genome-wide association studies of verbal tests (GenLang Consortium, five tests) and largely nonverbal tests (UK Biobank,

SUBMITTER: Procopio F 

PROVIDER: S-EPMC11882725 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature