Characteristics of oral mucositis in patients undergoing haploidentical stem cell transplantation with posttransplant cyclophosphamide: marked difference between busulfan and melphalan regimens.

ABSTRACT:

Purpose

This study was performed to examine the effects of conditioning regimens on oral mucositis in haploidentical (haplo) donor hematopoietic stem cell transplantation (HSCT) with posttransplant cyclophosphamide (PTCy).

Methods

Thirty consecutive patients (male, 23; female, 7; 18-68 years, median, 59 years) undergoing haplo-HSCT with PTCy using one of three conditioning regimens-reduced intensity conditioning (RIC)-melphalan (Mel); RIC-Busulfan (Bu); and myeloablative conditioning (MAC)-Bu-were enrolled in this study. Data on the WHO grade of oral mucositis (day - 7 to + 20) were collected retrospectively. The incidences of ulcerative and severe mucositis (Grade 2-4 and Grade 3-4, respectively) were compared between the three groups.

Results

Ulcerative mucositis oc

SUBMITTER: Ogura S 

PROVIDER: S-EPMC11882729 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature