Functional coverage of the human genome by existing structures, structural genomics targets, and homology models.

ABSTRACT: The bias in protein structure and function space resulting from experimental limitations and targeting of particular functional classes of proteins by structural biologists has long been recognized, but never continuously quantified. Using the Enzyme Commission and the Gene Ontology classifications as a reference frame, and integrating structure data from the Protein Data Bank (PDB), target sequences from the structural genomics projects, structure homology derived from the SUPERFAMILY database, and genome annotations from Ensembl and NCBI, we provide a quantified view, both at the domain and whole-protein levels, of the current and projected coverage of protein structure and function space relative to the human genome. Protein structures currently provide at least one domain that covers 3

SUBMITTER: Xie L 

PROVIDER: S-EPMC1188274 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature