The toll like receptor 7 pathway and the sex bias of systemic lupus erythematosus.

ABSTRACT: Systemic lupus erythematosus (SLE) predominately affects women with a ratio of females-to-males of about 9:1. The complement of sex chromosomes may play and important role in the mechanism of the sex bias. Previous work has shown that men with Klinefleter's syndrome (47,XXY) as well as women with 47,XXX are found in excess among SLE patients well as among Sjogren's disease, systemic sclerosis and idiopathic inflammatory myositis. in cells with more than one X chromosome, all but one is inactivated. However, X chromosome inactivation, as mediated by the long noncoding RNA X-inactive specific transcript, or XIST, is not complete with approximately 10% of genes in the non-recombining region of the X chromosome escaping X inactivation. In the TLR7 signaling pathway, both the TLR7 and TLR adapt

SUBMITTER: Scofield RH 

PROVIDER: S-EPMC11882868 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature