Identification of DAP3 as candidate prognosis marker and potential therapeutic target for hepatocellular carcinoma.

ABSTRACT:

Background

Among malignant tumors, hepatocellular carcinoma (HCC) is both prevalent and highly lethal. Most patients with advanced-stage liver cancer have a poor prognosis. Death-associated protein 3 (DAP3) is reportedly related to tumors and may hold great promise for the future.

Methods

DAP3 transcriptome data along with related clinical information were obtained from The Cancer Genome Atlas (TCGA), GEO, and ICGC databases. We assessed its prognostic value, clinical relevance, associated pathways, immune infiltration, gene mutations, and sensitivity to chemotherapeutics. A prognostic risk model was subsequently developed and evaluated using receiver operating characteristic (ROC) curves and Kaplan-Meier (KM) plots. Additionally, a nomogram was created and validated through

SUBMITTER: Yuan LX 

PROVIDER: S-EPMC11882876 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature