Structural analysis and core promoter prediction of STAR gene and its regulatory mechanism of progesterone synthesis in bovine luteal cells.

ABSTRACT: The steroidogenic acute regulatory protein (STAR) plays a crucial role in facilitating cholesterol transfer across the inner mitochondrial membrane during the process of steroidogenesis. However, the transcriptional regulation of the bovine STAR gene and its function of progesterone synthesis in luteal cells remain poorly understood. The objective of this study was to analyze the bovine STAR gene structure, identify its active promoter region, and explore its potential roles in progesterone synthesis. Bioinformatics analysis revealed that the bovine STAR gene encodes an 858-bp mRNA transcript, which translates into a protein consisting of 285 amino acids. The phylogenetic tree analysis showed that its genetic distance was closest to that of sheep. Notably, the promoter region of bovine STA

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC11882882 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature