Identification of candidate nsSNPs of the human FNDC5 gene and their structural and functional consequences using in silico analysis.

ABSTRACT: Fibronectin type-III domain containing protein-5 (FNDC5), predominantly expressed in skeletal muscles, encodes FNDC5 transmembrane-protein. A segment of this protein is cleaved and secreted into blood as irisin, which promotes browning of white adipose tissue, leading to energy expenditure. It functions synergistically with fibroblast growth factor-21 (FGF21). Irisin is considered as a potential target for treating obesity-related disorders. Likewise, FNDC5 variations can contribute to development of such disorders. This study aimed to identify putative non-synonymous single nucleotide polymorphisms (nsSNPs) of human FNDC5, potentially impacting FNDC5-FGF21 interaction. Sequence and structure based computational tools were used to identify nsSNPs of FNDC5, which revealed eight nsSNPs as be

SUBMITTER: Majeed S 

PROVIDER: S-EPMC11882896 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature