Weaker top-down cognitive control and stronger bottom-up signaling transmission as a pathogenesis of schizophrenia.

ABSTRACT: The clinical symptoms of schizophrenia are highly heterogeneous, with the most striking symptoms being cognitive deficits and perceptual disturbances. Cognitive deficits are typically linked to abnormalities in top-down mechanisms, whereas perceptual disturbances stem from dysfunctions in bottom-up processing. However, it remains unclear whether schizophrenia is primarily driven by top-down control mechanisms, bottom-up perceptual processes, or their interaction. We hypothesized that abnormal top-down and bottom-up interactions constitute the neural mechanisms of schizophrenia. Considering that autoencoders can identify hidden data features and support vector machines are capable of automatically locating the classification hyperplane, we developed an improved stacked autoencoder-support v

SUBMITTER: Lyu X 

PROVIDER: S-EPMC11883009 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature