Responses of the carotid artery to acute, fractionated or chronic ionizing irradiation, and differences from the aorta.

ABSTRACT: The circulatory system receives ionizing radiation at various dose rates. Given mounting epidemiological evidence of elevated radiation risks for diseases of the circulatory system (DCS), the International Commission on Radiological Protection recently recommended the first ever dose threshold for DCS. However, very little knowledge exists about whether radiation effects differ with dose rates and among tissues of the circulatory system. Here, we investigated the impact of dose rates in the carotid artery (CA) and compared it with the aorta. CA was obtained from mice irradiated with the same total dose that was delivered either acutely, 25 fractions, 100 fractions or chronically. CA underwent immunofluorescence and histochemistry staining. Irradiation led to vascular damage, inflammation a

SUBMITTER: Hamada N 

PROVIDER: S-EPMC11883035 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature