LncRNA ACVR2B-AS1 modulates thyroid cancer progression by regulating miR-195-5p.

ABSTRACT:

Background

lncRNAs are key regulators in thyroid cancer (TC). While lncRNA ACVR2B-AS1 has been proposed as a potential TC biomarker, its role remains underexplored. This study aims to clarify its clinical significance in TC and investigate its molecular mechanism.

Materials and methods

qRT-PCR was used to assess the expression of ACVR2B-AS1 in TC tissues and cell lines. Kaplan-Meier survival curves and Cox regression were utilized to assess the prognostic value of ACVR2B-AS1 expression. The interaction between ACVR2B-AS1 and miR-195-5p, as well as their effects on cell viability, migration, and invasion, were evaluated using dual-luciferase reporter assays, CCK-8 assays, and Transwell assays.

Results

ACVR2B-AS1 was significantly upregulated in TC tissues and cell line

SUBMITTER: Qin T 

PROVIDER: S-EPMC11883067 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature