PH-Activated Nanoplatform Derived from M1 Macrophages' Exosomes for Photodynamic and Ferroptosis Synergistic Therapy to Augment Cancer Immunotherapy.

ABSTRACT: Combining nanomedicine with immunotherapy offers a promising and potent cancer treatment strategy; however, improving the effectiveness of the antitumor immune response remains challenging. A "cold" tumor microenvironment (TME) is a marked factor affecting the efficacy of immunotherapy. Herein, intracellular-acidity-activatable dynamic nanoparticles (NPs) were designed for precision photodynamic immunotherapy and ferroptosis in cancer. M1 macrophage-derived exosomes (Mex) were constructed to coassemble the photosensitizer SR780, Fe³⁺, and the antioxidant enzyme catalase (CAT). By further modifying the RS17 peptides on the NPs, we increased their tumor-targeting capability and blocked the CD47-signal regulatory protein checkpoint, enabling macrophages to effectively phagocytose t

SUBMITTER: Guo Y 

PROVIDER: S-EPMC11883086 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature