Genomic alterations associated with early-stage disease and early recurrence in patients with colorectal cancer.

ABSTRACT:

Background

The molecular characterization of early-stage (1-3) colorectal cancer (CRC) remains incomplete, as opposed to metastatic disease, where comprehensive genomic profiling (CGP) is routinely performed. This study aimed to characterize the genomics of stages 1-3 versus IV CRC, and the genomics of patients recurring within 1 year of diagnosis.

Patients and methods

Patients from a de-identified CRC clinico-genomic database who received Foundation Medicine testing (FoundationOne/FoundationOne CDx) during routine clinical care at approximately 280 US cancer clinics between March 2014 and June 2023 were included. Genomic alterations (GA) were compared by Fisher's exact test.

Results

A total of 4702 patients were included; 1902 with stages 1-3 and 2800 with stage 4 di

SUBMITTER: Pappas L 

PROVIDER: S-EPMC11883158 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature