Evaluating early intervention in smoldering myeloma clinical trials: a systematic review.

ABSTRACT:

Background

Smoldering multiple myeloma (SMM), an asymptomatic precursor of multiple myeloma (MM), carries a variable risk of progression to MM. There is little consensus on the efficacy or optimal timing of treatment in SMM. We systematically reviewed the landscape of all clinical trials in SMM. We compared the efficacy of treatment regimens studied in SMM to results from these regimens when used in newly diagnosed multiple myeloma (NDMM), to determine whether the data suggest deeper responses in SMM versus NDMM.

Methods

All prospective interventional clinical trials for SMM, including published studies, meeting abstracts, and unpublished trials listed on ClinicalTrials.gov up to April 1, 2023, were identified. Trial-related variables were captured, including treatment strat

SUBMITTER: Kakkilaya A 

PROVIDER: S-EPMC11883161 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature