Identification and Characterization of a Novel GAPDH-Derived Antimicrobial Peptide From Jellyfish.

ABSTRACT: Marine organisms serve as a rich source of bioactive natural compounds, including antimicrobial agents. Jellyfish, which are ancient marine invertebrates with hundreds of millions of years of evolutionary history, have been in continuous contact with a diverse array of pathogenic microorganisms from seawater, which may give rise to a distinctive innate immune system and related defensive molecules. However, it is difficult and inefficient to isolate active ingredients directly from jellyfish for enrichment, though few jellyfish-sourced antimicrobial peptides (AMPs) have been reported. In this study, we utilized transcriptomic big data with bioinformatic tools to dig deeper into potential antimicrobial components in jellyfish, and identified a new AMP JFP-2826 from Rhopilema esculentum. The

SUBMITTER: Liu J 

PROVIDER: S-EPMC11883197 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature