CD163 detection in immune check-point inhibitors-related acute interstitial nephritis.

ABSTRACT:

Background

Acute interstitial nephritis (AIN) is the most common renal immune-related adverse event after immune check-point inhibitors (ICI). We hypothesized that alternatively activated macrophages (CD163-M) could be involved in ICI-AIN and wished to evaluate the use of their soluble urinary form (us)CD163 as a non-invasive diagnostic marker.

Methods

CD163-M infiltrates were evaluated by both immune-histochemistry and multiplex immunofluorescence and imaging. usCD163 was detected with ELLA technology and evaluated together with urinary creatinine to be expressed as a ratio to creatinuria in ng/mmol. Clinical data were collected to perform correlations with renal function assessed by estimated glomerular filtration rate (eGFR).

Results

A retrospective cohort of 63 IC

SUBMITTER: Perier T 

PROVIDER: S-EPMC11883220 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature