International validation of a pre-transplant risk assessment tool for graft survival in pediatric kidney transplant recipients.

ABSTRACT:

Background

A pre-transplant prediction model using commonly available factors is valuable for optimizing donor selection, communication, and counseling for pediatric kidney transplant (PKT) recipients. This study aims to externally validate a Dutch PKT prediction model and assess its international applicability.

Materials and methods

Data from the Dutch-, CERTAIN-, and CRISTAL registries, covering PKT from 2005 to 2021, were used. The Dutch prediction model was externally validated in a German and French cohort and then adapted to these specific countries. An international prediction model was also developed using all available data. Models were based on 80% derivation cohorts and internally validated using areas under the receiver operating characteristic curve (ROC-AUC) an

SUBMITTER: Oomen L 

PROVIDER: S-EPMC11883223 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature