Ear pinna growth and differentiation is conserved in murids and requires BMP signaling for chondrocyte proliferation.

ABSTRACT: Despite being a major target of reconstructive surgery, development of the ear pinna remains poorly studied. Here, we provide a cellular characterization of late gestational and postnatal ear pinna development in two rodents and investigate the role of BMP5 in expansion and differentiation of auricular elastic cartilage. We find that ear pinna development is largely conserved between Mus musculus and the highly regenerative Acomys dimidiatus. The pattern of pre-cartilaginous cells is established early in development. These cells are specified into chondroblasts before ear unfolding and then undergo extensive proliferation before maturation. The elastic cartilage, connective tissue fibroblasts, dermal papilla and sheath cells, and adipocytes in the adult pinna are derived from cranial neura

SUBMITTER: Allen RS 

PROVIDER: S-EPMC11883244 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature