Cadherins and growth factor receptors - ligand-selective mechano-switches at cadherin junctions.

ABSTRACT: This study investigated possible mechanisms underlying differences between heterophilic and homophilic cadherin adhesions that influence intercellular mechanics and multicellular organization. Results suggest that homophilic cadherin ligation selectively activates force transduction, such that resulting signaling and mechano-transduction amplitudes are independent of cadherin-binding affinities. Epithelial (E-) and neural (N-)cadherin cooperate with distinct growth factors to mechanically activate force transduction cascades. Prior results have demonstrated that E-cadherin and epidermal growth factor receptor form force-sensitive complexes at intercellular junctions. Here, we show that the reconstitution of N-cadherin force transduction requires the co-expression of N-cadherin and fibrobla

SUBMITTER: Vu V 

PROVIDER: S-EPMC11883276 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature