Rise in post-resection neutrophil-to-lymphocyte ratio correlates with decreased survival in glioblastoma patients.

ABSTRACT:

Background

Neutrophil-to-lymphocyte ratio (NLR) is used in the prognostication of multiple malignancies. However, the NLR value in glioblastoma (GBM) is controversial. This controversy may be due to the unaccounted effect of dexamethasone on NLR. Using retrospective data from 230 isocitrate dehydrogenase-1 (IDH) wild-type GBM patients, we studied the prognostic value of NLR in relation to dexamethasone treatment in GBM.

Methods

We retrospectively analyzed 230 patients with GBM. NLR and dexamethasone use were used as dichotomous variables with cutoff values of 9.5 and 8 mg, respectively. Correlations between high NLR, as well as NLR change after surgery, and patient outcome measures, including post-surgical complications and survival, were assessed using Kaplan-Meier c

SUBMITTER: Mohammad AH 

PROVIDER: S-EPMC11883344 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature