Carboplatin and vinblastine monthly in the optic pathway and hypothalamic gliomas: A retrospective analysis in a single institute.

ABSTRACT:

Background

Chemotherapy plays an important role in the treatment of optic pathway hypothalamic gliomas (OPHGs). Commonly used regimens include carboplatin and vincristine and monotherapy with vinblastine weekly. In this retrospective study, we used a monthly regimen of carboplatin and vinblastine to treat progressive/recurrent OPHGs and evaluated their effectiveness, visual preservation, and toxicity.

Methods

The study involved patients with OPGH who were treated with carboplatin and vinblastine once per month. The response, disease progression, overall survival, vision changes, and toxicity were recorded according to their medical charts at our institute, and survival was analyzed.

Results

A total of 25 patients were included, including 15 males (60%) and 10 females

SUBMITTER: Lin TB 

PROVIDER: S-EPMC11883347 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature