Exploring the therapeutic potential of Danggui Shaoyao San in nephrotic syndrome: Impact on skin sodium content and renal function.

ABSTRACT: The purpose of this study was to explore the mechanism of sodium transport in the skin of rats with nephrotic syndrome (NS) and the intervention effect of Danggui Shaoyao San (DSS). NS model was established by tail vein injection of adriamycin (ADR), and different doses of DSS, vascular endothelial growth factor receptor-3 (VEGFR-3) inhibitor Levatinib and diuretic amiloride were given for intervention. We analysed serum biochemical parameters, urine sodium, skin sodium and glycosaminoglycan (GAG), lymphatic vessel density, and the expression and mRNA levels of key proteins involved in lymphangiogenesis. The results showed that DSS treatment not only significantly reduced the content of sodium ions in the skin of NS rats, but also effectively alleviated the pathological damage of the kidne

SUBMITTER: Xiang Q 

PROVIDER: S-EPMC11883388 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature