Deep phenotyping of patients with MASLD upon high-intensity interval training.

ABSTRACT:

Background & aims

Exercise is a key component of lifestyle management in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but neither its therapeutic effect on the active stage of the disease, that is metabolic dysfunction-associated steatohepatitis (MASH) nor the mediating mechanisms have been characterized. Therefore, we performed multi-omic phenotyping of patients with MASLD-MASH on an exercise program.

Methods

Fifteen patients with MASLD conducted high-intensity interval training (HIIT) combined with home-based training for 12 weeks. MASLD was evaluated using histology, transient elastography, and multiparametric magnetic resonance imaging (MRI) before and after the intervention. Change in maximal oxygen consumption (VO_2max) and

SUBMITTER: Houttu V 

PROVIDER: S-EPMC11883402 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature